Irritable Bowel Syndrome with Diarrhea (IBS-D): For the treatment of IBS-D in adults.
Hepatic Encephalopathy (HE): For the reduction in risk of overt HE recurrence in patients ≥ 18 years of age.
Dosage and Administration
Hepatic Encephalopathy: 550 mg twice daily.
IBS-D: 550 mg three times a day for 14 days. Patients who experience a recurrence of symptoms and responded to the first treatment can be retreated for up to 2 times.
Contraindications
Hypersensitivity to rifaximin, rifamycin antimicrobial agents, or any ingredients in ZAXINE.
Warnings and Precautions
Not for Systemic Infections: Acts locally in the gut and should not be used for systemic infections.
Tendinitis and Tendon Rupture: Rare but serious, especially in older patients.
Clostridium difficile-Associated Diarrhea (CDAD): May occur with antibacterial use.
Hypersensitivity Reactions: Includes anaphylaxis, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
Hepatic Impairment: Increased systemic exposure; caution in severe hepatic impairment (Child-Pugh C).
Pregnancy: Use only if benefits justify risks.
Breastfeeding: Unknown if excreted in human milk; consider discontinuing drug or breastfeeding.
Pediatrics and Geriatrics: Safety and effectiveness not established in pediatric patients; no significant differences in safety or effectiveness in elderly.
