Form: Lyophilized powder for reconstitution with a diluent
Manufacturer: Bavarian Nordic A/S
Indications and Clinical Use
Pre-exposure Prophylaxis: For individuals at risk of contact with rabid animals (e.g., certain laboratory workers, veterinarians, animal handlers, travelers to endemic areas).
Post-exposure Prophylaxis: For all age groups following exposure to rabies.
Dosage and Administration
Pre-exposure Prophylaxis:
Primary Vaccination: Three doses (1.0 mL each) intramuscularly on days 0, 7, and 21 or 28.
Booster Doses: Administered based on serologic testing or every 2-5 years for continuous high-risk individuals.
Post-exposure Prophylaxis:
Previously Unvaccinated Individuals: Five doses (1.0 mL each) on days 0, 3, 7, 14, and 28, along with rabies immunoglobulin (RIG) on day 0.
Previously Vaccinated Individuals: Two doses (1.0 mL each) on days 0 and 3, without RIG.
Contraindications
Hypersensitivity to any component of the vaccine or to a previous dose.
Post-exposure prophylaxis should not be delayed or discontinued due to minor illnesses.
Warnings and Precautions
General: May not protect all individuals. Post-exposure prophylaxis should be started as soon as possible.
Immunocompromised Individuals: May have a reduced immune response.
Special Populations:
Pregnant Women: Use only if clearly needed.
Breastfeeding: Caution is advised.
Adverse Reactions
Very Common: Injection site reactions (pain, erythema, swelling), headache, malaise, myalgia, fever.
Common: Influenza-like illness, injection site induration, dizziness, rash.
