Hepatitis A: Prophylaxis is most effective when administered before or shortly after exposure.
Measles (Rubeola): Effective in preventing or modifying measles if given within 6 days of exposure. Recommended for susceptible individuals, particularly household contacts and immunocompromised persons.
Varicella: Used when Varicella-Zoster Immune Globulin (VZIG) is unavailable.
Rubella: Not routinely recommended but may lessen infection likelihood in exposed, susceptible pregnant women.
Contraindications
Hypersensitivity to the product or its components.
Individuals with isolated IgA deficiency.
Patients with severe thrombocytopenia or coagulation disorders.
Warnings and Precautions
For intramuscular injection only; not for intravenous or subcutaneous use.
Products made from human plasma may contain infectious agents; caution is advised.
Association with thromboembolic events; caution in patients with risk factors like obesity, hypertension, diabetes, etc.
Epinephrine should be available for managing acute allergic reactions.
Adverse Reactions
Common: Pain and tenderness at the injection site.
Severe: Anaphylaxis, angioedema, and urticaria are rare but possible.
Drug Interactions
Interference with live viral vaccines (e.g., measles, mumps, rubella); vaccination should be deferred for about 5 months post-administration.
Dosage and Administration
Hepatitis A: 0.1 mL/kg for contacts; higher doses for longer travel durations.
Measles: 0.25 mL/kg within 6 days of exposure.
Varicella: 0.6-1.2 mL/kg if VZIG is unavailable.
Rubella: 0.55 mL/kg for exposed, susceptible pregnant women.
Administer intramuscularly, preferably in the upper thigh or deltoid muscle; avoid gluteal region to prevent sciatic nerve injury.
Storage and Stability
Store at 2-8°C, do not freeze. Single-use vials must be discarded after opening.
Special Populations
Pregnant Women: Use only if clearly needed.
Nursing Women: Decision to use should consider potential risks to the infant.
Pediatrics: Safety and effectiveness not established.
Consumer Information
Provides antibodies to prevent or reduce the severity of infections like hepatitis A, measles, chickenpox, and rubella.
Discuss risks and benefits with a healthcare provider before use.
Potential side effects include injection site pain, allergic reactions, and, rarely, anaphylaxis.
